Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)-Reference-Cited by-同舟云学术

Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bergas Alba¹,Albasanz-Puig Adaia¹²^ORCID,Fernández-Cruz Ana³⁴,Machado Marina³,Novo Andrés⁵,van Duin David⁶^ORCID,Garcia-Vidal Carolina⁷,Hakki Morgan⁸,Ruiz-Camps Isabel⁹,del Pozo José Luis¹⁰,Oltolini Chiara¹¹,DeVoe Catherine¹²,Drgona Lubos¹³,Gasch Oriol¹⁴,Mikulska Malgorzata¹⁵,Martín-Dávila Pilar¹⁶,Peghin Maddalena¹⁷^ORCID,Vázquez Lourdes¹⁸,Laporte-Amargós Júlia¹,Durà-Miralles Xavier¹,Pallarès Natàlia¹⁹,González-Barca Eva²⁰,Álvarez-Uría Ana³,Puerta-Alcalde Pedro⁷,Aguilar-Company Juan⁹²¹,Carmona-Torre Francisco¹⁰,Clerici Teresa Daniela²²,Doernberg Sarah B.¹²,Petrikova Lucía¹³,Capilla Silvia²³,Magnasco Laura¹⁵,Fortún Jesús¹⁶,Castaldo Nadia¹⁷,Carratalà Jordi¹²,Gudiol Carlota¹²²⁴^ORCID

Affiliation:

1. Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Barcelona, Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

3. Clinical Microbiology and Infectious Diseases Department, General University Hospital Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

4. Infectious Disease Unit, Internal Medicine Department, Puerta de Hierro Hospital, Madrid, Spain

5. Hematology Department, Son Espases Hospital, Mallorca, Spain

6. Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA

7. Infectious Diseases Department, Hospital Clínic, Barcelona, Spain

8. Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA

9. Infectious Diseases Department, Vall d’Hebron University Hospital, Barcelona, Spain

10. Infectious Diseases Division, Clinical Microbiology, Clínica Universidad de Navarra, Immune and Infectious Inflammatory Diseases Research, IdiSNA, Pamplona, Spain

11. Unit of Infectious and Tropical Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

12. Infectious Diseases Division, Department of Medicine, University of California, San Francisco, California, USA

13. Oncohematology Department, Comenius University and National Cancer Institute, Bratislava, Slovakia

14. Infectious Diseases Department, Parc Taulí University Hospital, Sabadell, Spain

15. Division of Infectious Diseases, University of Genova and San Martino Hospital, Genoa, Italy

16. Infectious Diseases Department, Ramon y Cajal Hospital, Madrid, Spain

17. Infectious Diseases Clinic, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata, Udine, Italy

18. Hematology Service, Hospital Clínico Universitario, Salamanca, Spain

19. Statistics Advisory Service, Institute of Biomedical Research of Bellvitge, Barcelona, Spain

20. Hematology Department, Institut Català d’Oncologia (ICO), Hospital Duran i Reynals, IDIBELL, University of Barcelona, Barcelona, Spain

21. Department of Medical Oncology, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

22. Hematology Department, IRCCS San Raffaele Scientific Institute, Milan, Italy

23. Microbiology Department, Parc Taulí University Hospital, Sabadell, Spain

24. Institut Català d’Oncologia (ICO), Hospital Duran i Reynals, IDIBELL, Barcelona, Spain

Abstract

Ceftolozane-tazobactam (C/T) has been shown to be a safe and effective alternative for the treatment of difficult to treat infections due to Pseudomonas aeruginosa (PA) in the general nonimmunocompromised population. However, the experience of this agent in immunosuppressed neutropenic patients is very limited.

Funder

MEC | Instituto de Salud Carlos III

Merck & Co. | Merck Sharp and Dohme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02292-21

Reference37 articles.

1. Bacteraemia in febrile neutropenic cancer patients

2. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients