CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

Author:

Janssens Julie1ORCID,Blokken Jolien1,Lampi Yulia1,De Wit Flore1,Zurnic Bonisch Irena1,Nombela Ivan1,Van de Velde Paulien1,Van Remoortel Barbara1,Gijsbers Rik1,Christ Frauke1,Debyser Zeger1ORCID

Affiliation:

1. Laboratory of Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Flanders, Belgium

Abstract

Combination antiretroviral therapy (cART) effectively controls HIV-1 by reducing viral loads, but it does not cure the infection. Lifelong treatment with cART is a prerequisite for sustained viral suppression.

Funder

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Industrial Research fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Capsid–host interactions for HIV-1 ingress;Microbiology and Molecular Biology Reviews;2023-12-20

2. Nuclear transport proteins: structure, function, and disease relevance;Signal Transduction and Targeted Therapy;2023-11-10

3. Complex Relationships between HIV-1 Integrase and Its Cellular Partners;International Journal of Molecular Sciences;2022-10-15

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