CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import-Reference-Cited by-同舟云学术

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Janssens Julie¹^ORCID,Blokken Jolien¹,Lampi Yulia¹,De Wit Flore¹,Zurnic Bonisch Irena¹,Nombela Ivan¹,Van de Velde Paulien¹,Van Remoortel Barbara¹,Gijsbers Rik¹,Christ Frauke¹,Debyser Zeger¹^ORCID

Affiliation:

1. Laboratory of Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Flanders, Belgium

Abstract

Combination antiretroviral therapy (cART) effectively controls HIV-1 by reducing viral loads, but it does not cure the infection. Lifelong treatment with cART is a prerequisite for sustained viral suppression.

Funder

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Industrial Research fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01336-21

Reference63 articles.

1. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

2. Let me in: Control of HIV nuclear entry at the nuclear envelope

3. HIV-1 capsid: the multifaceted key player in HIV-1 infection

4. Transportin-SR2 Imports HIV into the Nucleus

5. Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

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