Aneuploidy Mediates Rapid Adaptation to a Subinhibitory Amount of Fluconazole in Candida albicans-Reference-Cited by-同舟云学术

Aneuploidy Mediates Rapid Adaptation to a Subinhibitory Amount of Fluconazole in Candida albicans

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Liu-liu¹²,Li Hao¹²,Yan Tian-hua²,Fang Ting¹,Wu Hao¹,Cao Yong-bing³,Lu Hui¹,Jiang Yuan-ying¹,Yang Feng¹^ORCID

Affiliation:

1. Department of Pharmacology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

2. Department of Physiology and Pharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

3. Institute of Vascular Disease, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Abstract

Genome instability is a hallmark of C. albicans . Aneuploidy usually causes fitness loss in the absence of stress but confers better fitness under particular stress conditions.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Innovation Program of Shanghai Municipal Education Commission

Shanghai Key Basic Research Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03016-22

Reference38 articles.

1. Epidemiology and Outcomes of Candidemia in 2019 Patients: Data from the Prospective Antifungal Therapy Alliance Registry

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