Whole-Genome Sequencing Reveals Differences among Kingella kingae Strains from Carriers and Patients with Invasive Infections-Reference-Cited by-同舟云学术

Whole-Genome Sequencing Reveals Differences among Kingella kingae Strains from Carriers and Patients with Invasive Infections

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Murik Omer¹^ORCID,Zeevi David A.¹,Mann Tzvia¹,Kashat Livnat²,Assous Marc V.²³,Megged Orli³⁴,Yagupsky Pablo⁵^ORCID

Affiliation:

1. Translational Genomics Laboratory, Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel

2. Microbiology Laboratory, Shaare Zedek Medical Center, Jerusalem, Israel

3. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

4. Pediatric Department and Infectious Diseases Unit, Shaare Zedek Medical Center, Jerusalem, Israel

5. Clinical Microbiology Laboratory, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Abstract

The wide range of clinical severities exhibited by invasive Kingella kingae infections strongly suggests that isolates differ in their genomic contents, and strains associated with life-threatening endocarditis may harbor distinct genomic determinants that result in cardiac tropism and severe tissue damage. The results of the present study show that no single gene discriminated between asymptomatically carried isolates and invasive strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03895-22

Reference39 articles.

1. The Contemporary Bacteriologic Epidemiology of Osteoarticular Infections in Children in Switzerland

2. Kingella kingae: Carriage, Transmission, and Disease

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4. Respiratory carriage of Kingella kingae among healthy children

5. Dissemination of Kingella kingae in the Community and Long-Term Persistence of Invasive Clones

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