Whole-Genome Sequencing Exhibits Better Diagnostic Performance than Variable-Number Tandem Repeats for Identifying Mixed Infections of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Whole-Genome Sequencing Exhibits Better Diagnostic Performance than Variable-Number Tandem Repeats for Identifying Mixed Infections of Mycobacterium tuberculosis

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Yiwang¹²,Jiang Qi³^ORCID,Liu Qingyun⁴,Gan Mingyu⁵,Takiff Howard E.⁶^ORCID,Gao Qian¹²^ORCID

Affiliation:

1. National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, Guangdong, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

3. School of Public Health, Public Health Research Institute of Renmin Hospital, Wuhan University, Wuhan, China

4. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

5. Molecular Medical Center, Children’s Hospital of Fudan University, Shanghai, China

6. Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela

Abstract

Mixed infections of M. tuberculosis have the potential to render treatment regimens ineffective and affect the transmission dynamics of the disease. VNTR typing, currently the most widely used method for the detection of mixed infections, detects mixed infections only by interrogating a small fraction of the M. tuberculosis genome, which necessarily limits sensitivity.

Funder

Shenzhen High-level Hospital Construction Fund

MOE | Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03570-22

Reference34 articles.

1. Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

2. Mixed Mycobacterium tuberculosis Complex Infections and False-Negative Results for Rifampin Resistance by GeneXpert MTB/RIF Are Associated with Poor Clinical Outcomes

3. Evaluation of the impact of polyclonal infection and heteroresistance on treatment of tuberculosis patients

4. Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines

5. A Microbiological Revolution Meets an Ancient Disease: Improving the Management of Tuberculosis with Genomics

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