Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis-Reference-Cited by-同舟云学术

Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Fan Ruyi¹²³,Zhou Yi¹²³,Chen Xu¹²³,Zhong Xianmei²⁴,He Fanzhen¹²,Peng Wenzao¹²,Li Lu¹²³,Wang Xiaoqian¹²³,Xu Yan¹²³

Affiliation:

1. Department of Periodontics, the Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China

2. Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China

3. Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China

4. Department of Periodontics, Taizhou Stomatological Hospital, Taizhou, China

Abstract

P. gingivalis is a bacterium often associated with periodontitis. This study demonstrates that (i) sRNA45033 in P. gingivalis OMVs targets CBX5, (ii) CBX5 regulates the methylation of p53 DNA and its expression, which is associated with apoptosis, and (iii) a novel mechanism of interaction between hosts and pathogens is mediated by OMVs in the occurrence of periodontitis.

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03288-22

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