A Versatile Nanoluciferase Reporter Reveals Structural Properties Associated with a Highly Efficient, N-Terminal Legionella pneumophila Type IV Secretion Translocation Signal-Reference-Cited by-同舟云学术

A Versatile Nanoluciferase Reporter Reveals Structural Properties Associated with a Highly Efficient, N-Terminal Legionella pneumophila Type IV Secretion Translocation Signal

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kang Yoon-Suk¹²,Kirby James E.¹²^ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

Abstract

Type IV secretion systems (T4SS) are used by Gram-negative pathogens to coopt host cell function. However, the translocation signals recognized by T4SS are not fully explained by primary amino acid sequence, suggesting yet-to-be-defined contributions of secondary and tertiary structure.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02338-22

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2. F factor conjugation is a true type IV secretion system

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4. Bacterial Type IV secretion systems: versatile virulence machines

5. Virulence factor secretion and translocation by Bordetella species

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