Identification of Hemagglutinin Mutations Caused by Neuraminidase Antibody Pressure-Reference-Cited by-同舟云学术

Identification of Hemagglutinin Mutations Caused by Neuraminidase Antibody Pressure

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Fei¹²,Wan Zhimin¹²,Wang Yajuan¹²,Wu Jinsen¹²,Fu Hui¹²,Gao Wei¹²,Shao Hongxia¹²³,Qian Kun¹²³,Ye Jianqiang¹²³^ORCID,Qin Aijian¹²³^ORCID

Affiliation:

1. Ministry of Education Key Laboratory for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu, China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

3. Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China

Abstract

HA binds with the sialic acid receptor on the host cell and initiates the infection mode of influenza virus. NA cleaves the connection between receptor and HA of newborn virus at the end of viral production.

Funder

MOST | National Key Research and Development Program of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01439-21

Reference46 articles.

1. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

2. Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics