Systemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV-Reference-Cited by-同舟云学术

Systemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Qiu Ming¹,Li Shubin¹,Ye Mengxue¹,Li Jixiang¹,Sun Zhe²,Li Xinshuai¹,Xu Yulin¹,Xiao Yanzhao¹,Li Chen¹,Feng Binghui¹,Lin Hong¹,Zheng Wanglong¹,Yu Xiuling²,Tian Kegong²,Zhu Jianzhong¹³⁴⁵,Chen Nanhua¹³⁴⁵^ORCID

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China

2. National Research Center for Veterinary Medicine, Luoyang, Henan, China

3. Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, Jiangsu, China

4. Comparative Medicine Research Institute, Yangzhou University, Yangzhou, Jiangsu, China

5. Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

Abstract

Porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV) coinfection occurs commonly and can synergistically reduce feed intake and pig growth. Vaccination is an effective strategy utilized for PED and PRRS control, and systemic homologous neutralizing antibodies (shnAbs) in serum are commonly used for protective efficacy evaluation of PED and PRRS vaccines.

Funder

National Natural Science Foundation of China

Open Project of Jiangsu Key Laboratory of Zoonosis

Priority Academic Program Development of Jiangsu Higher Education Institutions

Natural Science Foundation for Excellent Young Scholars of Jiangsu Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02574-21

Reference55 articles.

1. Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System

2. Two novel porcine epidemic diarrhea virus (PEDV) recombinants from a natural recombinant and distinct subtypes of PEDV variants

3. Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate

4. Study on the culture of porcine epidemic diarrhea virus adapted to fetal porcine intestine primary cell monolayer;Xuan H;Chin J Vet Sci,1984

5. Isolation and identification of porcine reproductive and respiratory syndrome (PRRS) virus from aborted fetuses suspected of PRRS;Guo B;Chin J Prev Vet Med,1996

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A chimeric porcine reproductive and respiratory syndrome virus 1 strain containing synthetic ORF2-6 genes can trigger T follicular helper cell and heterologous neutralizing antibody responses and confer enhanced cross-protection;Veterinary Research;2024-03-06

2. An Expeditious Neutralization Assay for Porcine Reproductive and Respiratory Syndrome Virus Based on a Recombinant Virus Expressing Green Fluorescent Protein;Current Issues in Molecular Biology;2024-01-23

3. Pathogenicity Studies of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus LNSY-GY and NADC30-like Porcine Reproductive and Respiratory Syndrome Virus GXGG-8011 in Piglets;Viruses;2023-11-11

4. Efficacy of a porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) natural recombinant against a heterologous PRRSV-1 isolate both clustered within the subgroup of BJEU06-1-like isolates;Veterinary Microbiology;2023-10

5. Progress in PRRSV Infection and Adaptive Immune Response Mechanisms;Viruses;2023-06-27