Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump <i>tmexC6D6-toprJ1b</i> and <i>tmexCD-toprJ</i> Variants-Reference-Cited by-同舟云学术

Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump tmexC6D6-toprJ1b and tmexCD-toprJ Variants

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Cheng-Zhen¹,Gao Xun¹,Liang Xin-Hong¹,Lv Lu-Chao¹,Lu Li-Tao¹,Yue Chao¹,Cui Xiao-Xiao¹,Yang Ke-Er¹,Lu Duo¹,Liu Jian-Hua¹²^ORCID,Yang Jun¹²^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, National Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in Animals, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

2. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China

Abstract

Tigecycline is one of the treatment options for serious infections caused by multidrug-resistant bacteria, and tigecycline resistance has gained extensive attention. The emergence of a transferable tigecycline resistance efflux pump gene cluster, tmexCD-toprJ , severely challenged the efficiency of tigecycline.

Funder

The Laboratory of Lingnan Modern Agriculture Project

The National Key Research and Development Program of China

The Guangdong Major Project of Basic and Applied Basic Research

The Guangdong Special Support Program Innovation Team

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00767-23

Reference19 articles.