A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tomasi Francesca G.¹^ORCID,Hall Alexander M. J.²,Schweber Jessica T. P.¹,Dulberger Charles L.¹,McGowen Kerry¹,Liu Qingyun¹,Fortune Sarah M.¹^ORCID,Helaine Sophie²,Rubin Eric J.¹^ORCID

Affiliation:

1. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

2. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

The global rise in antibiotic-resistant tuberculosis has prompted an urgent search for new drugs. Toxin-antitoxin (TA) systems allow bacteria to adapt rapidly to environmental changes, and Mycobacterium tuberculosis encodes more TA systems than any known pathogen.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00580-22

Reference46 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021.

2. Toxin-Antitoxin Systems in Clinical Pathogens