Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients-Reference-Cited by-同舟云学术

Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Lai Christopher K. C.¹,Cheung Man Kit¹^ORCID,Lui Grace C. Y.²,Ling Lowell³,Chan Jason Y. K.⁴^ORCID,Ng Rita W. Y.¹,Chan Hiu Ching¹,Yeung Apple C. M.¹,Ho Wendy C. S.¹,Boon Siaw Shi¹^ORCID,Chan Paul K. S.¹⁵^ORCID,Chen Zigui¹^ORCID

Affiliation:

1. Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China

2. Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China

3. Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China

4. Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR China

5. Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China

Abstract

Our results showed that while both COVID-19 and non-COVID-19 hospitalized patients differed in the composition, alpha and beta diversity, and metabolic potential of the naso-oropharyngeal microbiota compared with local controls, the microbial communities in the two hospitalized patient groups did not differ significantly from each other, indicating a limited impact of SARS-CoV-2 on the naso-oropharyngeal microbiota in hospitalized patients. Besides, we identified Alloprevotella and Solobacterium as bacterial genera uniquely enriched in COVID-19 patients, which may serve as more specific biomarkers for COVID-19 detection.

Funder

Research Grants Council, University Grants Committee

Food and Health Bureau

Chinese University of Hong Kong

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02196-22

Reference53 articles.

1. The Proportion of SARS-CoV-2 Infections That Are Asymptomatic