SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein-Reference-Cited by-同舟云学术

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Waisner Hope¹,Grieshaber Brandon¹,Saud Rabina¹,Henke Wyatt¹,Stephens Edward B.¹^ORCID,Kalamvoki Maria¹^ORCID

Affiliation:

1. University of Kansas Medical Center, Department of Microbiology, Molecular Genetics, and Immunology, Kansas City, Kansas, USA

Abstract

In late 2019, a new β-coronavirus, SARS-CoV-2, entered the human population causing a pandemic that has resulted in over 6 million deaths worldwide. Although closely related to SARS-CoV, the mechanisms of SARS-CoV-2 pathogenesis are not fully understood.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

KU | University of Kansas Medical Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03707-22

Reference81 articles.

1. Molecular Architecture of the SARS-CoV-2 Virus

2. The Coronavirus E Protein: Assembly and Beyond