Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step-Reference-Cited by-同舟云学术

Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Salgado-Benvindo Clarisse¹^ORCID,Leijs Anouk A.¹,Thaler Melissa¹^ORCID,Tas Ali¹,Arbiser Jack L.²³,Snijder Eric J.¹^ORCID,van Hemert Martijn J.¹^ORCID

Affiliation:

1. Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

2. Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA

3. Division of Dermatology, Veterans Affairs Medical Center, Decatur, Georgia, USA

Abstract

Honokiol is a compound that shows both anti-inflammatory and antiviral effects, and therefore its effect on SARS-CoV-2 infection was assessed. This small molecule inhibited SARS-CoV-2 replication in various cell-based infection systems, with up to an ~1,000-fold reduction in virus titer.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03273-22

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