A 77 Amino Acid Region in the N-Terminal Half of the HSV-1 E3 Ubiquitin Ligase ICP0 Contributes to Counteracting an Established Type 1 Interferon Response-Reference-Cited by-同舟云学术

A 77 Amino Acid Region in the N-Terminal Half of the HSV-1 E3 Ubiquitin Ligase ICP0 Contributes to Counteracting an Established Type 1 Interferon Response

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Perusina Lanfranca Mirna¹,van Loben Sels Jessica M.¹,Ly Cindy Y.¹,Grams Tristan R.²^ORCID,Dhummakupt Adit²,Bloom David C.²,Davido David J.¹

Affiliation:

1. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA

2. Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA

Abstract

Interferons (IFNs) are secreted cellular factors that are induced by viral infection and limit replication. HSV-1 is largely refractory to the antiviral effects of type 1 IFNs, which are synthesized shortly after viral infection, in part through the activities of the viral regulatory protein, ICP0.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

University of Kansas

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00593-22

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