Identification of Novel <i>tet</i> (X3) Variants Resistant To Tigecycline in Acinetobacter Species-Reference-Cited by-同舟云学术

Identification of Novel tet (X3) Variants Resistant To Tigecycline in Acinetobacter Species

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cheng Yumeng¹,Li Yakun²,Yu Runhao³,Ma Mingxiang¹,Yang Meng¹,Si Hongbin¹

Affiliation:

1. College of Animal Science and Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China

2. College of Life Science and Technology, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China

3. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China

Abstract

Although it is illegal to use tigecycline and carbapenems to treat bacterial infections in animals, we can still isolate bacteria containing both mobile resistance genes from animals, and tet (X) is currently an essential factor in degrading tigecycline. Here, we characterized two multidrug-resistant Acinetobacter sp. strains that contained vital resistance genes, such as sul2 , a bla OXA-164 -like gene, floR , tetM , and multiple novel tet (X3) variants with different tandem structures.

Funder

Key Research and Development Plan of Guangxi

Major R&D Project of Nanning Qingxiu District

Joint Funds of the National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01333-22

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1. Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris