Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii-Reference-Cited by-同舟云学术

Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Case Elizabeth Di Russo¹^ORCID,Mahapatra Saugata²,Hoffpauir Caitlyn T.²,Konganti Kranti³,Hillhouse Andrew E.³,Samuel James E.²,Van Schaik Erin J.²

Affiliation:

1. Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming, USA

2. Department of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, Texas, USA

3. Institute for Genome Sciences and Society, Texas A&M University, College Station, Texas, USA

Abstract

Coxiella burnetii, the causative agent of Q fever, preferentially infects macrophages of the respiratory tract when causing human disease. This work describes how primary macrophages respond toC. burnetiiat the earliest stages of infection, before bacterial replication.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02484-21

Reference49 articles.

1. VirulentCoxiella burnetiipathotypes productively infect primary human alveolar macrophages

2. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

3. Exposure to low doses of Coxiella burnetii caused high illness attack rates: Insights from combining human challenge and outbreak data