Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions

Author:

Peng Lei1ORCID,Guo Yang1ORCID,Gerhard Markus234ORCID,Gao Juan-Juan1,Liu Zong-Chao1,Mejías-Luque Raquel234,Zhang Lian1,Vieth Michael25,Ma Jun-Ling1,Liu Wei-Dong6,Li Zhe-Xuan12,Zhou Tong1,Li Wen-Qing12,You Wei-Cheng12,Zhang Yang12ORCID,Pan Kai-Feng12

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China

2. PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technische Universität München, Munich, Germany, and Peking University Cancer Hospital & Institute, Beijing, China

3. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany

4. German Center for Infection Research, Partner Site Munich, Munich, Germany

5. Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany

6. Linqu Public Health Bureau, Linqu, Shandong, China

Abstract

In this study, a panel was established including differential metabolites, genera, and their interactions, which may help to discriminate high-risk subjects for progression from mild lesions to advanced precancerous lesions in short-term and long-term follow-up.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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