Conserved GYXLI Motif of FlhA Is Involved in Dynamic Domain Motions of FlhA Required for Flagellar Protein Export-Reference-Cited by-同舟云学术

Conserved GYXLI Motif of FlhA Is Involved in Dynamic Domain Motions of FlhA Required for Flagellar Protein Export

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Minamino Tohru¹^ORCID,Kinoshita Miki¹,Inoue Yumi¹,Kitao Akio²,Namba Keiichi¹³⁴⁵

Affiliation:

1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

2. School of Life Science and Technology, Tokyo Institute of Technology, Meguro, Tokyo, Japan

3. RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

4. SPring-8 Center, Suita, Osaka, Japan

5. JEOL YOKOGUSHI Research Alliance Laboratories, Osaka University, Suita, Osaka, Japan

Abstract

Many motile bacteria employ the flagellar type III secretion system (fT3SS) to construct flagella beyond the cytoplasmic membrane. The C-terminal cytoplasmic domain of FlhA (FlhA C ), a transmembrane subunit of the fT3SS, provides binding sites for export substrates and flagellar export chaperones to coordinate flagellar protein export with assembly.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01110-22

Reference49 articles.

1. Flagella-Driven Motility of Bacteria

2. Protein export through the bacterial flagellar type III export pathway