Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata-Reference-Cited by-同舟云学术

Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yu Shuying¹²³,Paderu Padmaja¹,Lee Annie¹,Eirekat Sami⁴,Healey Kelley⁴^ORCID,Chen Liang¹⁵^ORCID,Perlin David S.¹⁵⁶,Zhao Yanan¹⁵^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China

3. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of China

4. Department of Biology, William Paterson University, Wayne, New Jersey, USA

5. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

6. Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC, USA

Abstract

As an important and successful human pathogen, Candida glabrata is known for its swift adaptation and rapid acquisition of resistance to the most commonly used antifungal agents, resulting in therapeutic failure in clinical settings. Here, we describe that the histone acetyltransferase Gcn5 is a key factor in adapting to antifungal pressure and developing resistance in C. glabrata .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00963-22

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