SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital-Reference-Cited by-同舟云学术

SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tsang Kara K.¹^ORCID,Ahmad Shehryar²^ORCID,Aljarbou Alanoud³,Al Salem Mohammed⁴,Baker Sheridan J. C.⁵⁶,Panousis Emily M.⁵⁶,Derakhshani Hooman⁷,Rossi Laura⁸⁹,Nasir Jalees A.⁵⁶^ORCID,Bulir David C.¹⁰,Surette Michael G.⁸⁹^ORCID,Lee Robyn S.¹¹,Smaill Fiona⁵¹⁰,Mertz Dominik⁵⁹^ORCID,McArthur Andrew G.⁵⁶^ORCID,Khan Sarah⁴⁵^ORCID

Affiliation:

1. Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

2. Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

3. Department of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

4. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada

5. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

6. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

7. Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada

8. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada

9. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

10. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

11. Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Abstract

Our manuscript describes a SARS-CoV-2 outbreak investigation in an Ontario tertiary care hospital. We use traditional contract tracing paired with whole-genome sequencing to facilitate an understanding of the evolutionary history and transmission dynamics of this SARS-CoV-2 outbreak in a clinical setting.

Funder

Canadian COVID Genomics Network (CanCOGeN) Virus Genome Sequencing Project

McMaster COVID-19 Research Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01900-22

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