Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma-Reference-Cited by-同舟云学术

Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Pratap Singh Raghwendra¹²,Kumari Naina³,Gupta Sameer⁴,Jaiswal Riddhi⁵,Mehrotra Divya⁶,Singh Sudhir⁷,Mukherjee Souvik³^ORCID,Kumar Rashmi¹²^ORCID

Affiliation:

1. Immunology Laboratory, Council for Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

3. Human Microbiome Research Laboratory, National Institute of Biomedical Genomics, Kalyani, West-Bengal, India

4. Department of Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India

5. Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India

6. Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India

7. Department of Radiology, King George’s Medical University, Lucknow, Uttar Pradesh, India

Abstract

The gut microbiome has been explored extensively for its importance in the modulation of systemic inflammation and immune response; in contrast, the intratumoral microbiome is less studied for its influence on immunity in cancer. Given the established correlation between intratumoral lymphocyte infiltration and patient survival in cases of solid tumors, it was pertinent to explore the extrinsic factor influencing immune cell infiltration in the tumor.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Council of Scientific and Industrial Research, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04596-22

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