The Impact of Long-Term Macrolide Exposure on the Gut Microbiome and Its Implications for Metabolic Control-Reference-Cited by-同舟云学术

The Impact of Long-Term Macrolide Exposure on the Gut Microbiome and Its Implications for Metabolic Control

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Choo Jocelyn M.¹²^ORCID,Martin Alyce M.³,Taylor Steven L.¹²,Sun Emily³,Mobegi Fredrick M.¹²,Kanno Tokuwa⁴,Richard Alyson¹²,Burr Lucy D.⁵⁶,Lingman Stevie⁵,Martin Megan⁵,Keating Damien J.³⁷,Mason A. James⁴^ORCID,Rogers Geraint B.¹²

Affiliation:

1. Microbiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

2. Infection and Immunity, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia

3. Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

4. Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King’s College London, London, United Kingdom

5. Department of Respiratory and Sleep Medicine, Mater Adult Hospital, Brisbane, Queensland, Australia

6. Respiratory and Infectious Disease Research Group, Mater Research Institute, Brisbane, Queensland, Australia

7. Nutrition & Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

Abstract

Long-term macrolide therapy is widely used in chronic respiratory diseases although its antibacterial activity can also affect the gut microbiota, a key regulator of host physiology. Macrolide-associated studies on the gut microbiota have been limited to short antibiotic courses and have not examined its consequences for host immune and metabolic regulation.

Funder

Betty Mcgrath Research Fellowship

DHAC | National Health and Medical Research Council

Thoracic Society of Australia and New Zealand

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00831-23

Reference57 articles.

1. British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease

2. Azithromycin in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa

3. Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

4. Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

5. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial