Development of CRISPR/Cas12b-Based Multiple Cross Displacement Amplification Technique for the Detection of Mycobacterium tuberculosis Complex in Clinical Settings

Author:

Yang Xinggui1ORCID,Huang Junfei1,Chen Yijiang1,Ying Xia1,Tan Qinqin1,Chen Xu2ORCID,Zeng Xiaoyan2,Lei Shiguang1,Wang Yi3,Li Shijun1

Affiliation:

1. Guizhou Provincial Center for Disease Control and Prevention, Guiyang, Guizhou, People’s Republic of China

2. Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, People’s Republic of China

3. Experimental Research Center, Capital Institute of Pediatrics, Beijing, People’s Republic of China

Abstract

The Mycobacterium tuberculosis complex pathogen is a crucial infectious agent of tuberculosis. Hence, improving the capability of MTC detection is one of the most urgently required strategies for preventing and controlling TB.

Funder

Cultivation Fund Project of the National Natural Science Foundation in Beijing Children’s Hospital, Capital Medical University

BMSTC | Beijing Nova Program

Guizhou Science and Technology Department

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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