Safety and Effectiveness of Isavuconazole Treatment for Fungal Infections in Solid Organ Transplant Recipients (ISASOT Study)

Author:

Monforte Arnau12,Los-Arcos Ibai12ORCID,Martín-Gómez Maria Teresa3,Campany-Herrero David4,Sacanell Judith5,Berastegui Cristina6,Márquez-Algaba Ester1,Sempere Abiu1,Nuvials Xavier5,Deu Maria7,Castells Lluís89,Moreso Francesc10,Bravo Carles6,Gavaldà Joan12,Len Oscar12

Affiliation:

1. Department of Infectious Diseases, Hospital Universitari Vall d’Hebron, Barcelona, Spain

2. Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

3. Department of Microbiology, Hospital Universitari Vall d’Hebron, Barcelona, Spain

4. Department of Pharmacy, Hospital Universitari Vall d’Hebron, Barcelona, Spain

5. Intensive Care Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain

6. Department of Pneumology, Hospital Universitari Vall d’Hebron, Barcelona, Spain

7. Department of Thoracic Surgery, Hospital Universitari Vall d’Hebron, Barcelona, Spain

8. Liver Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain

9. Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

10. Department of Nephrology, Hospital Universitari Vall d’Hebron, Barcelona, Spain

Abstract

We describe 53 solid organ transplant recipients treated with isavuconazole for fungal infections. Because its use in clinical practice, there is scarce data of its use in solid organ transplant recipients, where interactions with calcineurin inhibitors and mTOR and adverse drug events have limited the use of other triazoles.

Funder

Pfizer

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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