A High-Carbohydrate Diet Prolongs Dysbiosis and Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster Model of Infection-Reference-Cited by-同舟云学术

A High-Carbohydrate Diet Prolongs Dysbiosis and Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster Model of Infection

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bhute Shrikant S.¹,Mefferd Chrisabelle C.¹²,Phan Jacqueline R.³,Ahmed Muneeba¹⁴,Fox-King Amelia E.¹⁴,Alarcia Stephanie¹,Villarama Jacob V.¹⁵,Abel-Santos Ernesto³⁶^ORCID,Hedlund Brian P.¹⁶^ORCID

Affiliation:

1. School of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

2. School of Public Health, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

3. Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

4. College of Osteopathic Medicine, Touro University, Nevada, Henderson, Nevada, USA

5. Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

6. Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

Abstract

The effects of diet on CDI are not completely known. Here, we used a high-carbohydrate diet previously shown to protect mice against CDI to assess its effect on a hamster model of CDI and paradoxically found that it promoted dysbiosis, C. difficile carriage, and higher mortality.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01804-21

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