Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Author:

Geckin Büsra12,Zoodsma Martijn34,Kilic Gizem12ORCID,Debisarun Priya A.12,Rakshit Srabanti5,Adiga Vasista5,Ahmed Asma5,Parthiban Chaitra5,Kumar Nirutha Chetan5,D’Souza George5,Baltissen Marijke P.6,Martens Joost H. A.6,Domínguez-Andrés Jorge12ORCID,Li Yang134,Vyakarnam Annapurna57,Netea Mihai G.128

Affiliation:

1. Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands

2. Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

3. Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany

4. TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany

5. Laboratory of Immunology of HIV-TB Co-infection, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India

6. Department of Molecular Biology, Radboud University, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

7. Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences & Medicine, Guy’s Hospital, King’s College London, London, United Kingdom

8. Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany

Abstract

In this study, we assessed the differences in immune responses in individuals from India and Europe. This aspect is of great relevance, because of the described differences in morbidity and mortality between India and Europe during the pandemic.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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