Rapid and Accurate Antibiotic Susceptibility Determination of tet (X)-Positive E. coli Using RNA Biomarkers-Reference-Cited by-同舟云学术

Rapid and Accurate Antibiotic Susceptibility Determination of tet (X)-Positive E. coli Using RNA Biomarkers

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Haijie¹,Li Yan¹,Jiang Yongjia¹,Lu Xiaoyu¹^ORCID,Li Ruichao¹²³⁴^ORCID,Peng Daxin¹²⁴^ORCID,Wang Zhiqiang¹²⁴,Liu Yuan¹²³⁴^ORCID

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China

3. Institute of Comparative Medicine, Yangzhou University, Yangzhou, China

4. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, China

Abstract

Infections caused by multidrug-resistant (MDR) Gram-negative pathogens are an increasing threat to global health. Tigecycline is one of the last-resort antibiotics for the treatment of these complicated infections; however, the emergence of plasmid-encoded tigecycline resistance genes, namely, tet (X), severely diminishes its clinical efficacy.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Natural Science Foundation of Jiangsu Province

Jiangsu Agricultural Science and Technology Independent Innovation Fund

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00648-21