Decreased Interleukin-1 Family Cytokine Production in Patients with Nontuberculous Mycobacterial Lung Disease-Reference-Cited by-同舟云学术

Decreased Interleukin-1 Family Cytokine Production in Patients with Nontuberculous Mycobacterial Lung Disease

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Jung Bock-Gie¹^ORCID,Dean Kristin¹,Wadle Carly²,Samten Buka¹,Tripathi Deepak¹,Wallace Richard J.³,Brown-Elliott Barbara A.³^ORCID,Tucker Torry⁴,Idell Steven⁴⁵,Philley Julie V.²,Vankayalapati Ramakrishna¹

Affiliation:

1. Department of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

2. Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

3. Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

4. Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA

5. The Texas Lung Injury Institute, Tyler, Texas, USA

Abstract

Upon MAC stimulation, the production of IL-1 family cytokines and IL-10 by PBMCs of NTMPD patients was attenuated compared with that of healthy household contacts. Upon MAC stimulation, the expression of TLR2 and TWIK2 (one of the two-pore domain K+ channels) was attenuated in PBMCs of NTMPD patients compared with that of healthy household contacts.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03110-22

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