Calibrating Hepatitis E Virus Serological Assays Using Asymptomatic Specimens Obtained in Japan

Author:

Terahara Kazutaka1ORCID,Li Tian-Cheng2,Matsubayashi Keiji3,Sakata Hidekatsu4ORCID,Kato Takanobu2,Naganuma Atsushi5,Ogawa Koji6,Honda Koichi7,Itakura Jun8,Akutsu Noriyuki9,Tobita Hiroshi10,Korenaga Masaaki11,Kanto Tatsuya11,Sugiyama Ryuichi2,Suzuki Ryosuke2ORCID,Hamaguchi Isao12,Isogawa Masanori1ORCID,Takahashi Yoshimasa1ORCID

Affiliation:

1. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

3. Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan

4. Japanese Red Cross Hokkaido Block Blood Center, Sapporo, Japan

5. Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Gunma, Japan

6. Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan

7. Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan

8. Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan

9. Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Hokkaido, Japan

10. Department of Hepatology, Shimane University Faculty of Medicine, Shimane, Japan

11. Hepatitis Information Center, Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan

12. Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan

Abstract

Accurate diagnosis of hepatitis E virus (HEV) infection is essential for public health surveillance and for preventing HEV-contaminated blood transfusion. Anti-HEV IgM or IgA is used as a reliable marker of recent HEV infection.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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