Role of Enzymatic Activity in the Biological Cost Associated with the Production of AmpC β-Lactamases in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Role of Enzymatic Activity in the Biological Cost Associated with the Production of AmpC β-Lactamases in Pseudomonas aeruginosa

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Barceló Isabel M.¹²³,Jordana-Lluch Elena¹²,Escobar-Salom María¹²³,Torrens Gabriel¹²³⁴⁵,Fraile-Ribot Pablo A.¹²³,Cabot Gabriel¹²³^ORCID,Mulet Xavier¹²³,Zamorano Laura¹²³,Juan Carlos¹²³^ORCID,Oliver Antonio¹²³^ORCID

Affiliation:

1. Research Unit, University Hospital Son Espases-Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain

2. Microbiology Department, University Hospital Son Espases, Palma, Spain

3. Centro de Investigación Biomédica en Red, Enfermedades Infecciosas, Madrid, Spain

4. Department of Molecular Biology, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden

5. Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden

Abstract

The growing antibiotic resistance of the top nosocomial pathogen Pseudomonas aeruginosa pushes research to explore new therapeutic strategies, for which the resistance-versus-virulence balance is a promising source of targets. While resistance often entails significant biological costs, little is known about the bases of the virulence attenuations associated with a resistance mechanism as extraordinarily relevant as β-lactamase production.

Funder

Direcció General de Política Universitària i Recerca, Govern Illes Balears

Govern de les Illes Balears

MEC | Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02700-22

Reference65 articles.