Antigenic Characterization and Pandemic Risk Assessment of North American H1 Influenza A Viruses Circulating in Swine

Author:

Venkatesh Divya1ORCID,Anderson Tavis K.2ORCID,Kimble J. Brian2,Chang Jennifer2,Lopes Sara1,Souza Carine K.2,Pekosz Andrew3ORCID,Shaw-Saliba Kathryn4ORCID,Rothman Richard E.4,Chen Kuan-Fu5,Lewis Nicola S.16,Vincent Baker Amy L.2ORCID

Affiliation:

1. Royal Veterinary College, London, United Kingdom

2. National Animal Disease Center, USDA-ARS, Ames, Iowa, USA

3. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

4. Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

5. Department of Emergency Medicine of Chang Gung Memorial Hospital at Keelung, Keelung City, Taiwan

6. OIE/FAO International Reference Laboratory for Avian Influenza, Swine Influenza and Newcastle Disease, Animal and Plant Health Agency (APHA), Weybridge, Addlestone, Surrey, United Kingdom

Abstract

Human H1 influenza A viruses (IAV) spread to pigs in North America, resulting in a sustained circulation of two major groups of H1 viruses in swine. We quantified the genetic diversity of H1 in swine and measured antigenic phenotypes.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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