High-Throughput Mutagenesis Reveals a Role for Antimicrobial Resistance- and Virulence-Associated Mobile Genetic Elements in Staphylococcus aureus Host Adaptation-Reference-Cited by-同舟云学术

High-Throughput Mutagenesis Reveals a Role for Antimicrobial Resistance- and Virulence-Associated Mobile Genetic Elements in Staphylococcus aureus Host Adaptation

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ba Xiaoliang¹^ORCID,Matuszewska Marta¹²,Kalmar Lajos¹,Fan Jingyan³,Zou Geng³,Corander Desirée⁴,Raisen Claire L.¹,Li Shaowen³,Li Lu³⁵⁶,Weinert Lucy A.¹,Tucker Alexander W.¹,Grant Andrew J.¹^ORCID,Zhou Rui³⁵⁶^ORCID,Holmes Mark A.¹

Affiliation:

1. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

2. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

3. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University College of Veterinary Medicine, Wuhan, China

4. Department of Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland

5. Cooperative Innovation Centre of Sustainable Pig Production, Wuhan, China

6. International Research Centre for Animal Diseases (MOST), Wuhan, China

Abstract

CC398 is the dominant type of methicillin-resistant Staphylococcus aureus (MRSA) in European livestock and a growing cause of human infections. Previous studies have suggested MRSA CC398 evolved from human-associated methicillin-sensitive Staphylococcus aureus and is capable of rapidly readapting to human hosts while maintaining antibiotic resistance.

Funder

National Natural Science Foundation of China

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04213-22

Reference60 articles.

1. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management