Cell-Based Platform for Antigen Testing and Its Application for SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Cell-Based Platform for Antigen Testing and Its Application for SARS-CoV-2 Infection

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ssemadaali Marvin A.¹^ORCID,Newmyer Sherri¹,Radhakrishnan Harikrishnan¹,Arredondo Juan²,Javitz Harold S.³,Dandekar Satya²,Bhatnagar Parijat¹^ORCID

Affiliation:

1. Biosciences Division, SRI International, Menlo Park, California, USA

2. Medical Microbiology and Immunology, University of California Davis, Davis, California, USA

3. Education Division, SRI International, Menlo Park, California, USA

Abstract

Pandemic mitigation requires continuous testing of symptomatic or asymptomatic individuals with rapid turnaround time, and lack of this capability in our community has prolonged pandemic duration leading to obliteration of world economies. The DxCell platform is a cell-based self-replicative antigen test that detects molecular signatures of the target pathogen and can be distributed in small quantities to testing facilities for expansion on site to the desired volume.

Funder

DOD | Defense Advanced Research Projects Agency

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00731-22

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1. Emergence of a novel human coronavirus threatening human health