Core Genome Multilocus Sequence Typing and Antibiotic Susceptibility Prediction from Whole-Genome Sequence Data of Multidrug-Resistant Pseudomonas aeruginosa Isolates

Author:

Cunningham Scott A.1,Eberly Allison R.1ORCID,Beisken Stephan2,Posch Andreas E.2,Schuetz Audrey N.1ORCID,Patel Robin13ORCID

Affiliation:

1. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

2. Ares Genetics GmbH, Vienna, Austria

3. Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

Multidrug-resistant Pseudomonas aeruginosa isolates are a serious public health concern due to their resistance to nearly all or all of the available antibiotics, including carbapenems. Utilizing molecular approaches in conjunction with antibiotic susceptibility prediction software warrants investigation for use in the clinical laboratory workflow.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference38 articles.

1. Microbe Profile: Pseudomonas aeruginosa: opportunistic pathogen and lab rat

2. Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

3. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

4. Centers for Disease Control and Prevention National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) Division of Healthcare Quality Promotion (DHQP). 2021. Antibiotic Resistance Threats in the United States 2019. https://www.cdc.gov/drugresistance/biggest-threats.html.

5. World Health Organization. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed.

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