Insights into the Effects and Mechanism of Andrographolide-Mediated Recovery of Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Insights into the Effects and Mechanism of Andrographolide-Mediated Recovery of Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ma Qiang¹,Wang Guilai²,Li Na¹,Wang Xin¹,Kang Xinyun¹,Mao Yanni¹,Wang Guiqin¹

Affiliation:

1. Veterinary Pharmacology Lab, College of Agriculture, Ningxia University, Yinchuan, Ningxia, China

2. Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, Ningxia, China

Abstract

Increasingly, alternatives to antibiotics are being used to mitigate the rapid onset and development of bacterial resistance, and the combination of natural compounds with traditional antibiotics has become an effective therapeutic strategy. Therefore, we attempted to discover more mechanisms to restore susceptibility and effective dosing strategies.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Ningxia Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02978-22

Reference49 articles.

1. β-lactam antibiotics: An overview from a medicinal chemistry perspective

2. Bacterial TEM-type serine beta-lactamases: structure and analysis of mutations