Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress-Reference-Cited by-同舟云学术

Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Zhixin¹²³,Fu Yanan¹²,Huang Yanping¹²,Zeng Feng¹²,Rao Jingjing¹²,Xiao Xiao¹²,Sun Xiaoguang¹²,Jin Hao¹,Li Jian¹²^ORCID,Yang Jing¹²,Du Weixing¹,Liu Long¹²³^ORCID

Affiliation:

1. Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China

2. Institute of Virology, Hubei University of Medicine, Shiyan, China

3. Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China

Abstract

Viruses struggle to reproduce after infecting cells, and the host eliminates infected cells through apoptosis to prevent virus spread. Cells adopt a special ubiquitination code to protect against viral infection, while ORF7a manipulates and exploits the ubiquitin system to eliminate host cells' effect on apoptosis and redirect cellular pathways in favor of virus survival.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01509-22

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