Genomic Analysis Revealed the International and Domestic Transmission of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in Chinese Pediatric Patients-Reference-Cited by-全球学者库

Genomic Analysis Revealed the International and Domestic Transmission of Carbapenem-Resistant Klebsiella pneumoniae in Chinese Pediatric Patients

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Jiang Muxiu¹^ORCID,Li Heng²³,Liu Xiao²,Shen Nan¹,Zhou Yuanjie¹,Song Wenting¹,Wang Xing⁴,Cao Qing¹,Zhou Zhemin²³^ORCID

Affiliation:

1. Department of Infectious Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

2. Pasteurien College, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China

3. Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, Suzhou, Jiangsu, China

4. Department of Laboratory Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection in pediatric patients differs from that in adults patients in terms of both genetic and phenotypic features, which remain to be elucidated. We present a summary of prevalent CRKP isolates from Chinese pediatric patients over 8 years, demonstrating the prevalence and clinical importance of New Delhi metallo-β-lactamase genes in pediatric patients, mainly describing the genomic features of two predominant CRKP clones (ST11 and ST14) in Chinese children, and identifying four carbapenemase-encoding plasmids that contribute to the transmission of most carbapenemase genes in hospitals.

Funder

2021 Shanghai University teacher training plan-industry university research practice plan project

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03213-22

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