Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients-Reference-Cited by-同舟云学术

Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Santos Bravo Marta¹^ORCID,Tilloy Valentin²,Plault Nicolas²³,Palomino Sonsoles Sánchez⁴,Mosquera María Mar¹,Navarro Gabriel Mireia¹,Fernández Avilés Francesc⁵,Suárez Lledó María⁵,Rovira Montserrat⁵,Moreno Asunción⁶,Linares Laura⁶,Bodro Marta⁶,Hantz Sébastien²³,Alain Sophie²³,Marcos María Ángeles¹

Affiliation:

1. Microbiology Department, Hospital Clínic I Provincial de Barcelona, University of Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain

2. National Reference Center for Herpesviruses, Microbiology Department, CHU Limoges, Limoges, France

3. UMR Inserm 1092, University of Limoges, Limoges, France

4. AIDS Research Group, Institut D’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic I Provincial de Barcelona, University of Barcelona, Barcelona, Spain

5. Bone Marrow Transplant Unit, Hematology Department, Hospital Clínic I Provincial de Barcelona, Barcelona, Spain

6. Infectious Diseases Department, Hospital Clínic I Provincial de Barcelona, Barcelona, Spain

Abstract

We provide comprehensive data on the clinical correlates of both CMV genotypic follow-up by standard and deep sequencing and the clinical outcomes, as well as recombinant phenotypic results of this novel mutation. Our study emphasizes that the clinical follow-up in combination with genotypic and phenotypic studies is essential for the assessment and optimization of patients experiencing HCMV relapses or not responding to antiviral therapy.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00191-22

Reference27 articles.

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3. In Vitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246