Functional analysis of the Candida albicans <i>ECE1</i> Promoter-Reference-Cited by-同舟云学术

Functional analysis of the Candida albicans ECE1 Promoter

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Garbe Enrico¹,Thielemann Nadja²,Hohner Sina²,Kumar Animesh²,Vylkova Slavena¹^ORCID,Kurzai Oliver²³⁴^ORCID,Martin Ronny²^ORCID

Affiliation:

1. Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

2. Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

3. Research Group Fungal Septomics, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

4. National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

Abstract

In recent years it was shown that secretion of the toxic peptide candidalysin from hyphae of the major human fungal pathogen Candida albicans contributes heavily to its virulence. The peptide is derived from a precursor protein which is encoded by the ECE1 gene whose transcription is known to be closely associated with formation of hyphae.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00253-23

Reference44 articles.

1. Candidalysin is a fungal peptide toxin critical for mucosal infection

2. Candidalysin triggers epithelial cellular stresses that induce necrotic death