Identification of HLA-A*24:02-Restricted CTL Candidate Epitopes Derived from the Nonstructural Polyprotein 1a of SARS-CoV-2 and Analysis of Their Conservation Using the Mutation Database of SARS-CoV-2 Variants-Reference-Cited by-同舟云学术

Identification of HLA-A*24:02-Restricted CTL Candidate Epitopes Derived from the Nonstructural Polyprotein 1a of SARS-CoV-2 and Analysis of Their Conservation Using the Mutation Database of SARS-CoV-2 Variants

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Takagi Akira¹,Matsui Masanori²^ORCID

Affiliation:

1. School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, Yamane, Hidaka-city, Saitama, Japan

2. Department of Microbiology, Faculty of Medicine, Saitama Medical University, Morohongo, Moroyama-cho, Iruma-gun, Saitama, Japan

Abstract

COVID-19 vaccines have been designed to elicit neutralizing antibodies against the Spike protein of the original SARS-CoV-2, and hence they are less effective against variants. It is possible that novel variants will appear and escape from vaccine-elicited immunity.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01659-21

Reference45 articles.

1. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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4. COVID-19 vaccines: modes of immune activation and future challenges

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