Variants of Streptococcus pneumoniae Serotype 14 from Papua New Guinea with the Potential to Be Mistyped and Escape Vaccine-Induced Protection

Author:

Manna Sam123ORCID,Spry Leena1,Wee-Hee Ashleigh1,Ortika Belinda D.1,Boelsen Laura K.1,Batinovic Steven4,Mazarakis Nadia1,Ford Rebecca L.5,Lo Stephanie W.6ORCID,Bentley Stephen D.6,Russell Fiona M.12,Blyth Christopher C.789,Pomat William S.5,Petrovski Steve4,Hinds Jason1011,Licciardi Paul V.12,Satzke Catherine123

Affiliation:

1. Infection and Immunity, Murdoch Children’s Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia

2. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia

3. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia

4. Department of Microbiology, Anatomy, Physiology, and Pharmacology, La Trobe University, Bundoora, Victoria, Australia

5. Infection and Immunity Unit, Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands, Papua New Guinea

6. Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom

7. Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute and School of Medicine, University of Western Australia, Perth, Australia

8. Department of Infectious Diseases, Perth Children’s Hospital, Perth, Australia

9. Department of Microbiology, PathWest Laboratory Medicine, Perth, Australia

10. Institute for Infection and Immunity, St. George's, University of London, United Kingdom

11. BUGS Bioscience, London Bioscience Innovation Centre, London, United Kingdom

Abstract

Pneumococcus is a pathogen of major public health importance. Current vaccines have limited valency, targeting a subset (up to 20) of the more than 100 capsule types (serotypes).

Funder

Department of Health | National Health and Medical Research Council

Robert Austrian Award

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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