Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity-Reference-Cited by-同舟云学术

Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Teh Wooi Keong¹,Ding Yichen¹,Gubellini Francesca²^ORCID,Filloux Alain¹³,Poyart Claire⁴,Givskov Michael¹⁵^ORCID,Dramsi Shaynoor⁶⁷^ORCID

Affiliation:

1. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore

2. Institut Pasteur, Unité de Microbiologie Structurale, Paris, France

3. Centre for Bacterial Resistance Biology, Department of Life Sciences, Imperial College London, London, United Kingdom

4. Université de Paris, Assistance Publique Hôpitaux de Paris, Service de Bactériologie, Centre National de Référence des Streptocoques, Groupe Hospitalier Paris Centre site Cochin, Paris, France

5. Costerton Biofilm Centre, Department of Immunology and Microbiology, University of Copenhagen, Denmark

6. Institut Pasteur, Université Paris Cité, CNRS UMR6047, Biology of Gram-positive Pathogens Unit, Paris, France

7. Centre National de la Recherche Scientifique (CNRS) UMR2001, Paris, France

Abstract

In this study, 38 clinical isolates of Streptococcus gallolyticus subsp. gallolyticus ( SGG ) were sequenced and a genetic locus encoding the type VIIb secretion system (T7SSb) was found conserved and absent from 16 genomes of the closely related S. gallolyticus subsp. pasteurianus ( SGP ). The T7SSb is a bona fide pathogenicity island.

Funder

Agence Nationale de la Recherche

Institut National Du Cancer

Singapore Centre for Environmental Life Sciences Engineering

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01481-23

Reference82 articles.

1. Genome Sequence ofStreptococcus gallolyticus: Insights into Its Adaptation to the Bovine Rumen and Its Ability To Cause Endocarditis