Exposure to Secreted Bacterial Factors Promotes HIV-1 Replication in CD4 <sup>+</sup> T Cells-Reference-Cited by-同舟云学术

Exposure to Secreted Bacterial Factors Promotes HIV-1 Replication in CD4 ⁺ T Cells

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Znaidia M.¹,de Souza-Angelo Y.¹,Létoffé S.²,Staropoli I.¹,Grzelak L.¹,Ghigo J. M.²^ORCID,Schwartz O.¹³^ORCID,Casartelli N.¹^ORCID

Affiliation:

1. Institut Pasteur, Université Paris-Cité, UMR CNRS 3569, Virus and Immunity Unit, Paris, France

2. Institut Pasteur, Université Paris-Cité, UMR CNRS 6047, Genetics of Biofilms Laboratory, Paris, France

3. Vaccine Research Institute, Créteil, France

Abstract

People living with HIV suffer from chronic immune activation despite effective antiretroviral therapy. Early after infection, HIV-1 actively replicates in the gut, causing the breakage of the intestinal epithelial barrier and microbial translocation.

Funder

Agence Nationale de Recherches sur le Sida et les Hépatites Virales

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04313-22

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