A New Potential Resource in the Fight against Candida auris: the <i>Cinnamomum zeylanicum</i> Essential Oil in Synergy with Antifungal Drug-Reference-Cited by-同舟云学术

A New Potential Resource in the Fight against Candida auris: the Cinnamomum zeylanicum Essential Oil in Synergy with Antifungal Drug

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Di Vito M.¹^ORCID,Garzoli S.²,Rosato R.¹,Mariotti M.¹,Gervasoni J.³,Santucci L.³,Ovidi E.⁴,Cacaci M.¹⁵,Lombarini G.¹,Torelli R.⁵,Urbani A.³,Sanguinetti M.¹⁵^ORCID,Bugli F.¹⁵

Affiliation:

1. Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy

2. Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma Sapienza, Rome, Italy

3. UOC Chimica, Biochimica e Biologia Molecolare Clinica, Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

4. Department for Innovation in Biological, Agro-Food and Forest Systems DIBAF—University of Tuscia, Viterbo, Italy

5. Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

Abstract

This study highlights how small doses of CZ-EO are able to inhibit the secretion of fluconazole and promote its accumulation in the fungal cell. In this manner, the drug is able to exert its pharmacological effects bypassing the resistance of the yeast. If further studies will confirm this synergy, it will be possible to develop new therapeutic formulations active in the fight against C. auris resistances.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04385-22

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