Persistent and Severe Viral Replication in PBMCs with Moderate Immunosuppression Served an Alternative Novel Pathogenic Mechanism for Canine Morbillivirus-Reference-Cited by-同舟云学术

Persistent and Severe Viral Replication in PBMCs with Moderate Immunosuppression Served an Alternative Novel Pathogenic Mechanism for Canine Morbillivirus

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Feng Chuchu¹²,Bu Yan¹²,Cai Jiaxi¹²,Zhao Guanyu³,Li Zishu¹²,Cheng Yuening¹²,Zhang Xiaohao⁴,Shi Yijun⁵,Gao Yang¹²,Li Xiangnan⁶,Zheng Xuexing⁷,Xue Xianghong¹²^ORCID

Affiliation:

1. Department of Viral Infectious Diseases of Special Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China

2. Jilin Provincial Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China

3. College of Veterinary Medicine, Jilin University, Changchun, Jilin, China

4. Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, China

5. Department of Product Quality and Safety, Yantai Animal Disease Control Center, Yantai, Shandong, China

6. Department of Fur Animal Business, Jilin Teyan Biotechnology Co., Ltd., Changchun, Jilin, China

7. Department of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

Abstract

Despite widespread vaccine campaigns for domestic dogs, CDV remained an important infectious disease in vaccinated carnivores and wild species. In recent years, the regionally ongoing epidemic CDV isolates have emphasized conservation threats to, and potentially disastrous epidemics in, endangered species worldwide.

Funder

National Natural Science Foundation of China

Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Agricultural Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04060-22

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