Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis-Reference-Cited by-同舟云学术

Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chiang Ming-Hsien¹^ORCID,Chang Fang-Ju¹,Kesavan Dinesh Kumar²,Vasudevan Aparna³⁴,Xu Huaxi³⁴,Lan Kuo-Lun⁵,Huang Shu-Wei⁶^ORCID,Shang Hung-Sheng⁵^ORCID,Chuang Yi-Ping⁷⁸,Yang Ya-Sung⁹,Chen Te-Li¹⁰^ORCID

Affiliation:

1. Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan

2. School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore

3. International Genomics Research Centre (IGRC), Jiangsu University, Zhenjiang, China

4. Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China

5. Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

6. Department of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

7. Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan

8. Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan

9. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

10. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

Abstract

Elizabethkingia anophelis is a bacterium often associated with nosocomial infection. This study demonstrated that imipenem-induced E. anophelis outer membrane vesicles (OMVs) are immunologically relevant and crucial for bacterial survival under antibiotic stress conditions rather than being a source of antibiotic resistance.

Funder

Ministry of Science and Technology, Taiwan

Tri-Service General Hospital

MOD | Medical Affairs Bureau

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00262-22

Reference49 articles.

1. Elizabethkingia meningoseptica: emerging multidrug resistance in a nosocomial pathogen