Conjugative Transfer of Acute Hepatopancreatic Necrosis Disease-Causing pVA1-Type Plasmid Is Mediated by a Novel Self-Encoded Type IV Secretion System

Author:

Wang Dehao12,Wang Liying13,Bi Dexi4,Song Jipeng1,Wang Guohao1,Gao Ye1,Tang Kathy F. J.1,Meng Fanzeng13,Xie Jingmei15,Zhang Fan1,Huang Jie16ORCID,Li Jianliang2,Dong Xuan15ORCID

Affiliation:

1. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Laboratory for Marine Fisheries Science and Food Production Processes, Pilot National Laboratory for Marine Science and Technology (Qingdao), Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Qingdao, China

2. Shandong Agricultural University, College of Animal Science and Veterinary Medicine, Tai’an, China

3. Shanghai Ocean University, Shanghai, China

4. Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

5. Tianjin Agricultural University, Tianjin, China

6. Network of Aquaculture Centres in Asia-Pacific, Bangkok, Thailand

Abstract

The pathogenic pVA1-type plasmids that carry pirAB toxin genes are the genetic basis for Vibrio to cause acute hepatopancreatic necrosis disease (AHPND), a lethal shrimp disease posing an urgent threat to shrimp aquaculture. Emerging evidence also demonstrate the rapid spread of pVA1-type plasmids across Vibrio species.

Funder

MOA | CAFS | Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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