Capsicumicine, a New Bioinspired Peptide from Red Peppers Prevents Staphylococcal Biofilm In Vitro and In Vivo via a Matrix Anti-Assembly Mechanism of Action

Author:

Gomes Von Borowski Rafael12ORCID,Chat Sophie1,Schneider Rafael12,Nonin-Lecomte Sylvie3,Bouaziz Serge3,Giudice Emmanuel1,Rigon Zimmer Aline2,Baggio Gnoatto Simone Cristina2,Macedo Alexandre José24,Gillet Reynald1ORCID

Affiliation:

1. Université de Rennes, CNRS, Institut de Génétique et de Développement de Rennes (IGDR), UMR6290, Rennes, France

2. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

3. Université de Paris, CNRS, CiTCoM (Cibles Thérapeutiques et Conception de Médicaments) UMR 8038, Faculté de Pharmacie, Paris, France

4. Centro de Biotecnologia da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Abstract

Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. So far, no effective treatments targeting the bacteria in biofilms have been developed.

Funder

Capes Cofecub

CNRS

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference70 articles.

1. World Health Organization. 2015. WHO Library Cataloguing-in-Publication data. Global action plan on antimicrobial resistance. I. World Health Organization Geneva Switzerland.

2. World Health Organization. 2018. WHO competency framework for health workers’ education and training on antimicrobial resistance. World Health Organization Geneva Switzerland. https://www.who.int/hrh/resources/WHO-HIS-HWF-AMR-2018.1/en. Accessed 12 January 2019.

3. Antibiotic Discovery: Combatting Bacterial Resistance in Cells and in Biofilm Communities

4. The biofilm matrix

5. Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals

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