Molecular Insight into Gene Response of Diorcinol- and Rubrolide-Treated Biofilms of the Emerging Pathogen Stenotrophomonas maltophilia-Reference-Cited by-同舟云学术

Molecular Insight into Gene Response of Diorcinol- and Rubrolide-Treated Biofilms of the Emerging Pathogen Stenotrophomonas maltophilia

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Gudzuhn Mirja¹,Alio Ifey¹^ORCID,Moll Raphael¹,de Vries Jessica²,Boehlich Jacob³,Assmann Maik³,Janneschütz Jasmin²,Schützenmeister Nina²,Himmelbach Axel⁴,Poehlein Anja⁵^ORCID,Daniel Rolf⁵^ORCID,Streit Wolfgang R.¹^ORCID

Affiliation:

1. Department of Microbiology and Biotechnology, Universität Hamburg, Hamburg, Germany

2. Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria

3. Department of Chemistry, Institute of Pharmacy, Universität Hamburg, Hamburg, Germany

4. Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Seeland, Germany

5. Institute of Microbiology and Genetics, Department of Genomic and Applied Microbiology, Georg-August University of Göttingen, Göttingen, Germany

Abstract

Combating Stenotrophomonas maltophilia biofilms in clinical and industrial settings has proven to be challenging. S. maltophilia is multidrug resistant, and occurrence of resistance to commonly used drugs as well as to antibiotic combinations, such as trimethoprim-sulfamethoxazole, is now frequently reported. It is therefore now necessary to look beyond conventional and already existing antimicrobial drugs when battling S. maltophilia biofilms.

Funder

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02582-21

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5. Multiple-drug–resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease: Prevalence, risk factors, and outcome*

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